Publications

(* denotes joint first or senior authorship)

2017



Castillo-Fernandez JE, Loke YJ, Bass-Stringer S, Gao F, Xia Y, Wu H, Lu H, Liu Y, Wang J, Spector TD, Saffery R, Craig JM*, Bell JT*. 2017. DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. Genome Medicine, 9:28. doi:10.1186/s13073-017-0413-5. Link. Highlighted in The Conversation

Wahl S*, Drong A*, Lehne B*, Loh M*, Scott WR*, Kunze S, Tsai P-C, Ried JS, Zhang W, Yang Y, Tan S, Fiorito G, Franke L, Guarrera S, Kasela S, Kriebel J, Richmond RC, Adamo M, Afzal U, Ala-Korpela M, Albetti B, Ammerpohl O, Apperley JF, Beekman M, Bertazzi PA, Black SL, Blancher C, Bonder M-J, Brosch M, Carstensen-Kirberg M, De Craen AJM, Lusignan S, Dehghan A, Elkalaawy M, Fischer K, Franco O, Gaunt TR, Hampe J, Hashemi M, Isaacs A, Jenkinson A, Jha S, Kato N, Krogh V, Laffan M, Meisinger C, Meitinger T, Mok ZY, Motta V, Ng HK, Nikolakopoulou Z, Nteliopoulos G, Panico S, Pervjakova N, Prokisch H, Rathmann W, Roden M, Rota F, Rozario MA, Sandling JK, Schafmayer C, Schramm K, Siebert R, Slagboom E, Soininen P, Stolk L, Strauch K, Tai E-S, Tarantini L, Thorand B, Tigchelaar EF, Tumino R, Uitterlinden AG, van Duijn C, van Meurs JBJ, Vineis P, Wickremasinghe AR, Wijmenga C, Yang T-P, Yuan W, Zhernakova A, Batterham R, Davey Smith G, Deloukas P, Heijmans BT, Herder C, Hofman A, Lindgren CM, Milani L, van der Harst P, Peters A, Illig T, Relton CL, Waldenberger M, Jarvelin M-R, Bollati V, Soong R, Spector TD, Scott J, McCarthy MI, Elliott P, Bell JT*, Matullo G*, Gieger C*, Kooner JS*, Grallert H*, Chambers JC*. 2017. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541(7635):81-86. Link

2016



Roos L, Sandling JK, Bell CG, Glass D, Mangino M, Spector TD, Deloukas P, Bataille V*, and Bell JT*. 2016. Higher naevus count exhibits a distinct DNA methylation signature in healthy human skin: implications for melanoma. Journal of Investigative Dermatology, in press. doi: 10.1016/j.jid.2016.11.029. Link

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, METASTROKE, UK Young Lacunar DNA Resource, NINDS Stroke Genetics Network, Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Slowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PIW, McArdle PF, Woo D, Anderson CD, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CLM, Rothwell PM, Boncoraglio G, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, and Markus HS. 2016. Genetic Variation in a 16q24.2 locus that influences DNA methylation and expression of ZCCHC14 is associated with small vessel stroke. Annals of Neurology, accepted. doi: 10.1002/ana.24840. Link

Davenport ER, Goodrich JK, Bell JT, Spector TD, Ley RE, Clark AG. 2016. ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins. BMC Genomics, 17(1):941. doi: 10.1186/s12864-016-3290-1. Link

Beaumont M, Goodrich JK, Jackson MA, Yet I, Davenport ER, Vieira-Silva S, Debelius J, Pallister T, Mangino M, Raes J, Knight R, Clark AG, Ley RE, Spector TD*, Bell JT*. 2016. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biology, 17(1):189. doi: 10.1186/s13059-016-1052-7. Link. Highlighted in BBC CNN Reuters Time Magazine Financial Times Genome Biology Best of 2016

Zierer J, Pallister T, Tsai PC, Bell JT, Lauc G, Spector TD, Menni C, Kastenmuller G. 2016. Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model. Scientific Reports, 6:37646. doi: 10.1038/srep37646. Link

Jackson MA, Bell JT, Spector TD, Steves CJ. 2016. A heritability-based comparison of methods used to cluster 16S rRNA gene sequences into operational taxonomic units. PeerJ, 4:e2341. doi: 10.7717/peerj.2341. Link

Marzi C, Holdt LM, Fiorito G, Tsai P-C, Kretschmer A, Wahl S, Guarrera S, Teupser D, Spector TD, Iacoviello L, Sacerdote C, Strauch K, Lee S, Thasler WE, Peters A, Thorand B, Wolf P, Prokisch H, Tumino R, Gieger C, Krogh V, Panico S, Bell JT, Matullo G, Waldenberger M, Grallert H, Koenig W. 2016. Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues. PLoS ONE, 11(11):e0166015. doi: 10.1371/journal.pone.0166015. Link

Xie H, Guo R, Zhong H, Feng Q, Lan Z, Qin B, Ward KJ, Jackson MA, Xia Y, Chen X, Chen B, Xia H, Xu C, Li F, Xu X, Yousuf Al-Aama J, Yang H, Wang J, Kristiansen K, Wang J, Steves CJ, Bell JT, Li J, Spector TD, Jia H. 2016. Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome. Cell Systems, 3(6):572-584.e3. doi: 10.1016/j.cels.2016.10.004. Link

Liu C*, Marioni RE*, Hedman AK*, Pfeiffer L*, Tsai P-C*, Reynolds LM*, Just AC*, Duan Q*, Boer CG*, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Khnel B, Herder C, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love S-A, Guan W, Shah S, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL, Almli LM, Smith AK, Binder EB, Ressler KJ, Irvin R, Absher DM, Hernandez D, Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling J, Stolk L, Uitterlinden AG, Yet I, Castillo-Fernandez J, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett DK, Sotoodehnia N, Ong KK, van Meurs JBJ, Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE*, Liu Y*, Waldenberger M*, London SJ*, Ingelsson E*, Levy D*. 2016. A DNA Methylation Biomarker of Alcohol Consumption. Molecular Psychiatry. doi: 10.1038/mp.2016.192. Link

Bell CG, Xia Y, Yuan W, Gao F, Ward K, Roos L, Mangino M, Hysi PG, Bell J, Wang J, and Spector TD. 2016. Novel regional age-associated DNA methylation changes within human common disease-associated loci. Genome Biology, 17(1):193, doi: 10.1186/s13059-016-1051-8. Link

Chen BH*, Marioni RE*, Colicino E*, Peters MJ, Ward-Caviness CK, Tsai P-C, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling L, Price TR, Singleton AR, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W, Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AR, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D*, Baccarelli A*, van Meurs J*, Bell JT*, Peters P*, Deary IJ*, Pankow JS*, Ferrucci L*, Horvath S*. 2016. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY). 8(9):1844-1859. doi: 10.18632/aging.101020. Link

Livshits G, Gao F, Malkin I, Needhamsen M, Xia Y, Yuan W, Bell CG, Ward K, Liu Y, Wang J*, Bell JT*, Spector TD*. 2016. Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins. J Clin Endocrin Metab, 101(6): 2450-2459. Link

Goodrich JK, Davenport ER, Beaumont M, Jackson MA, Knight R, Spector TD, Bell JT, Clark AG, Ley RE. 2016. Genome wide association study of the gut microbiome in UK Twins. Cell Host Microbe 19(5): 731-743. Link

Yet I, Menni C, Shin S-Y, Mangino M, Soranzo N, Adamski J, Suhre K, Spector TD, Kastenmller G*, Bell JT*. Genetic influences on metabolite levels: a comparison across metabolomic platforms. PLoS One, 11(4): e0153672. Link

Roos L, van Dongen J, Bell CG, Burri A, Deloukas P, Boomsma DI, Spector TD, Bell JT. 2016. Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pair. Clinical Epigenetics, 8:7. Link

Jackson MA, Jeffery IB, Beaumont M, Bell JT, Clark AG, O’Toole PW, Ley RE, Spector TD, Steves CJ. 2016. Signatures of early frailty in the gut microbiota. Genome Medicine 8:8. Link

Al Muftah WA, Al-Shafai M, Zaghlool SB, Visconti A, Tsai PC, Kumar P, Spector T, Bell J, Falchi M, Suhre K. 2016. Epigenetic associations of type 2 diabetes and BMI in an Arab population. Clinical Epigenetics, 8:13. Link

Zierer J, Kastenmller G, Suhre K, Gieger C, Codd V, Tsai P-C, Bell J, Peters A, Strauch K, Schulz H, Weidinger S, Mohney RP, Samani NJ, Spector T, Mangino M, and Menni C. 2016. Metabolomics profiling reveals novel markers for leukocyte telomere length. Aging 8:1. Link

Yet I, Tsai P-C, Castillo-Fernandez J, Carnero-Montoro E, and Bell JT. 2016. Genetic and environmental impacts on DNA methylation levels in twins. Epigenomics, 8(1):105-117. Link

Jackson MA, Goodrich JK, Maxan M-E, Freedberg DE, Abrams JA, Poole AC, Sutter JL, Welter D, Ley RE, Bell JT, Spector TD, Steves CJ. 2015. Proton Pump Inhibitors alter the composition of the gut microbiota. Gut, doi:10.1136/gutjnl-2015-310861. Link

Busche S, Shao X, Caron M, Kwan T, Allum F, Cheung W, Ge B, Westfall S, Simon M-M, The Multiple Tissue Human Expression Resource, Barrett A, Bell JT, Mark I McCarthy MI, Deloukas P, Blanchette M, Bourque G, Spector TD, Lathrop M, Pastinen T, Grundberg E. 2015. Population whole-genome bisulfite sequencing across two tissues highlights environment as principal source of human methylome variation. Genome Biology, 16:290. Link

2015



Tsai P-C, van Dongen J, Tan Q, Willemsen G, Christiansen L, Boomsma DI, Spector TD, Valdes AM*, Bell JT*. DNA methylation changes in the IGF1R gene in birth weight discordant adult monozygotic twins. Twin Research and Human Genetics, 13:1-12. Link

Jackson MA, Goodrich JK, Maxan M-E, Freedberg DE, Abrams JA, Poole AC, Sutter JL, Welter D, Ley RE, Bell JT, Spector TD, Steves CJ. 2015. Proton Pump Inhibitors alter the composition of the gut microbiota. Gut, doi: 10.1136/gutjnl-2015-310861 Link

Busche S, Shao X, Caron M, Kwan T, Allum F, Cheung W, Ge B, Westfall S, Simon M-M, The Multiple Tissue Human Expression Resource, Barrett A, Bell JT, Mark I Mc- Carthy MI, Deloukas P, Blanchette M, Bourque G, Spector TD, Lathrop M, Pastinen T, Grundberg E. 2015. Population whole-genome bisulfite sequencing across two tissues highlights environment as principal source of human methylome variation. Genome Biology, 16:290. Link

Yet I, Tsai P-C, Castillo-Fernandez J, Carnero-Montoro E, and Bell JT. Genetic and environmental impacts on DNA methylation levels in twins. Epigenomics, Epigenomics, 8(1):105-117. doi: 10.2217/epi.15.90. Link

Blekhman R, Goodrich JK, Huang K, Sun Q, Bukowski R, Bell JT, Spector TD, Keinan A, Ley RE, Gevers D, Clark AG. 2015. Host genetic variation impacts microbiome composition across human body sites. Genome Biology, 161:191. Link

Barrios C*, Beaumont M*, Pallister T, Villar J, Goodrich JK, Clark A, Pascual J, Ley RE, Spector TD, Bell JT, Menni C. 2015. Gut-microbiota-metabolite axis in early renal function decline. PLoS One, 10: e0134311. Link

Tsai P-C and Bell JT. 2015. Power and Sample Size Estimation for Epigenome-Wide Association Scans to Detect Differential DNA Methylation. International Journal of Epidemiology, doi: 10.1093/ije/dyv041. Link

Mangino M, Cecelja M, Menni C, Tsai P-C, Yuan W, Small K, Bell J, Mtchell GF, AortaGen Consortium, Chowienczyk P, Spector TD. 2016. Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity. Journal of Hypertension, 34(1):79-87. doi: 10.1097/HJH.0000000000000732. Link

Martin TC, Yet I, Tsai P-C, and Bell JT. 2015. coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns. BMC Bioinformatics, 16:131. doi:10.1186/s12859-015-0568-2. Link

Draisma HHM. Pool R, Kobl M, Jansen R, Petersen A-K, Vaarhorst A, Yet I, Haller T, Demirkan A, Esko T, Zhu G, Bohringer S, Beekman M, van Klinken JB, Prehn C, Adamski J, de Craen A, van Leeuwen E, Amin N, Dharuri H, Westra H-J, Franke L, de Geus E, Hottenga J-J, Willemsen G, Henders A, Montgomery G, Nyholt D, Whitfield J, Penninx B, Spector TD, Metspalu A, Slagboom E, van Dijk KW, Hoen PT, Strauch K, Martin N, van Ommen G-J, Illig T, Bell J, Mangino M, Suhre K, McCarthy M, Gieger C, Isaacs A, van Duijn C, and Boomsma D. 2015. Genome- wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nature Communications, 6:7208. doi:10.1038/ncomms8208. Link

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab S, Min J, Walter K, Memari Y, Huang J, Barnes M, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Celia Greenwood CMT, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry J, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng H-F, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector TD, Davey-Smith G, Durbin R, Richards JB, Soranzo N, Timpson NJ, Wilson SG and the UK10K Consortium. 2015. Whole genome sequence based analysis of thyroid function. Nature Communications, 6: 5681. doi:10.1038/ncomms6681. Link

Zhang W, Spector TD, Deloukas P, Bell JT*, Engelhardt BE*. 2015. Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements. Genome Biology, 16: 14. Link

2014



Yuan W*, Xia Y*, Bell CG, Yet I, Ferreira T, Ward K, Gao F, Loomis AK, Hyde CL, Wu H, Lu H, Liu Y, Small K, Vinuela A, Morris A, Berdasco M, Esteller M, Brosnan JM, Deloukas P, McCarthy MI, John SL, Bell JT*, Wang J*, Spector TD*. An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nature Communications, 5: 5719. doi:10.1038/ncomms6719. Link

Tsaprouni LG, Yang T-P, Bell JT, Dick KJ, Kanoni S, Nisbet J, Vinuela A, Grundberg E, Nelson CP, Meduri E, Buil A, the MuTHER consortium, Cambien F, Hengstenberg C, Erdmann J, Schunkert H, Goodall AH, Ouwehand WH, Dermitzakis E, Spector TD, Samani N, and Deloukas P. Cigarette Smoking Reduces DNA Methylation Levels at Multiple Genomic Loci but the Effect is Partially Reversible upon Cessation. Epigenetics, 9:1382-96. Link

Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, Beaumont M, Van Treuren W, Knight R, Bell JT, Spector TD, Clark A, and Ley RE. 2014. Human Genetics Shape the Gut Microbiome. Cell, 159(4): 789-799. doi:10.1016/j.cell.2014.09.053. Link. Highlighted in New Scientist F1000

Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schnfels W, Ahrens M, Heits N, Bell JT, Tsai P-C, Spector TD, Deloukas P, Siebert R, Sipos B, Becker T, Rcken C, Schafmayer C, Hamped J. 2014. Obesity accelerates epigenetic aging of human liver. PNAS, 111(43):15538-43. doi: 10.1073/pnas. Link

Wolber L, Steves CJ, Tsai P-C, Deloukas P, Spector TD, Bell JT*, Williams FMK*. 2014. Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. PLoS One, 9(9):e105729. doi:10.1371/journal.pone.0105729. Link

Castillo-Fernandez JE, Spector, TD, and Bell JT. 2014. Epigenetics of discordant monozygotic twins: implications for disease. Genome Medicine. 6(7): 60. doi: 10.1186/s13073-014-0060-z. Link

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, Tsernikova N, Luan J, Mihailov J, Ehret GB, Zhang W, Lamparter D, Esko T, Mace A, Reger S, Bochud P-Y, Barcella M, Dauvilliers Y, Benyamin B, Evans DM, Hayward C, Lopez MF, Franke L, Russo A, Heid IM, Salvi E, Vendantam S, Arking DE, Boerwinkle E, Chambers JC, Fiorito G, Grallert H, Guarrera S, Homuth G, Huffman JE, Porteous D, Generation Scotland Consortium, The LifeLines Cohort study, The GIANT Consortium, Moradpour D, Iranzo A, Hebebrand J, Kemp JP, Lammers GJ, Aubert V, Heim MH, Martin NG, Montgomery GW, Peraita-Adrados R, Santamaria J, Negro F, Schmidt CO, Scott RA, Spector TD, Strauch K, Volzke H, Wareham NJ, Yuan W, Bell JT, Chakravarti A, Kooner JS, Peters A, Matullo G, Wallaschofski H, Whitfield JB, Paccaud F, Vollenweider P, Bergmann S, Beckmann JS, Tafti M, Hastie ND, Cusi D, Bochud M, Frayling TM, Metspalu A, Jarvelin M-R, Scherag A, Davey Smith G, Borecki IB, Rousson V, Hirschhorn JN, Rivolta C, Loos RJF, Kutalik Z. 2014. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent of origin effect on body mass index. PLoS Genetics, 10(7):e1004508. doi: 10.1371/journal.pgen.1004508. Link

Davies MN*, Lutz Krause L*, Bell JT*, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai PC, Collier DA, Mill J, UK Brain Expression Consortium, Henders A, Byrne E, Wray NR, Martin NG*, Spector TD* and Wang J*. 2014. Hypermethylation in the ZBTB20 gene is associated with Major Depressive Disorder: A Discordant Monozygotic Twin study. Genome Biology, 15:R56. doi: 10.1186/gb-2014-15-4-r56. Link

Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J, Scollen S, Davies MN, Schalkwyk LC, Mill J, The MuTHER Consortium, Williams FMK, Li N, Deloukas P, Beck S, McMahon SB, Wang J, John SL, and Spector TD. 2014. Differential methylation of TRPA1 promoter is associated with pain sensitivity. Nature Communications, 5:2978. doi:10.1038/ncomms3978. Link. Highlighted in BBC New Scientist Forbes

2013



Menni C, Keser T, Mangino M, Bell JT, Erte I, Akmacic I, Vuckovic F, Pucic Bakovic M, Gornik O, McCarthy M, Zoldos V, Spector TD, Lauc G, Valdes AM. 2013. Glycosylation of Immunoglobulin G: Role of genetic and epigenetic influences. PLoS One, 8:e82558. doi: 10.1371/journal.pone.0082558. Link

Grundberg E, Meduri E, Sandling JK, Hedman AK, Keildson S, Nisbet J, Sekowska M, Wilk A, Barrett A, Small KS, Ge B, Carone M, Shin S-Y, Dermitzakis ET, McCarthy MI, Spector TD, Bell JT, Deloukas P. 2013. Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements. American Journal of Human Genetics, 93: 876-890. doi: 10.1016/j.ajhg.2013.10.004. Link

Menni C, Fauman E, Erte I, Perry J, Kastenmller G, Shin S-Y, Petersen A-K, Hyde C, Psatha M, Ward K, Yuan W, Milburn M, Palmer C, Frayling T, Trimmer J, Bell JT, Gieger C, Mohney R, Brosnan M, Suhre K, Soranzo N, Spector T. 2013. Biomarkers for type 2 diabetes and impaired fasting glucose using a non-targeted metabolomics approach. Diabetes, 62(12):4270-6. doi: 10.2337/db13-0570. Link

Di Rienzi SC, Sharon I, Wrighton KC, Koren O, Hug LA, Thomas BC, Goodrich JK, Bell JT, Spector TD, Banfield JF and Ley RE. 2013. The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria. eLife, 2:e01102. doi: 10.7554/eLife.01102. Link

Menni C, Kastenmuller G, Petersen AK, Psatha M, Bell JT, Tsai P-C, Gieger C, Schulz H, Erte I, John S, Brosnan MJ, Wilson SG, Lim EM, Stuckey BGA, Mohney RP, Suhre K, Spector TD, and Valdes AM. 2013. Metabolomic markers reveal novel pathways of aging and early development in human populations. International Journal of Epidemiology, 42(4):1111-9, doi: 10.1093/ije/dyt094. Link

Drong AW, Nicholson G, Hedman AK, Meduri E, Grundberg E, Small KS, Shin S-Y, Bell JT, Karpe F, Soranzo N, Spector TD, McCarthy MI, Deloukas P, Rantalainen M, Lindgren C, for the MolPAGE Consortia. 2013. The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of methylation in adipose tissue. PLoS One, 8(2):e55923. Link

2012



Tsai P-C, Spector TD, and Bell JT. 2012. Using Epigenome-Wide Association Scans of DNA Methylation for Age-Related Complex Human Traits. Epigenomics, 4: 511- 526. Link

Williams FM, Bansal AT, van Meurs JB, Bell JT, Meulenbelt I, Suri P, Rivadeneira F, Sambrook PN, Hofman A, Bierma-Zeinstra S, Menni C, Kloppenburg M, Slagboom PE, Hunter DJ, Macgregor AJ, Uitterlinden AG, Spector TD. 2012. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Annals of Rheumatic Diseases, doi:10.1136/annrheumdis- 2012-201551. Link

Heyn H, Carmona FJ, Gomez A, Ferreira HJ, Bell JT, Sayols S, Ward K, Stefansson OA, Moran S, Sandoval J, Eyfjord JE, Spector TD, Esteller M. 2012. DNA methyla- tion profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. Carcinogenesis, 34(1):102-8. Link

Bell JT and Spector TD. 2012. DNA methylation studies using twins: What are they telling us? Genome Biology, 13(10):172. Link

Grundberg E*, Small KS*, Hedman AK*, Nica AC*, Buil A*, Keildson S, Bell JT, Yang T-P, Barett A, Nisbet J, Wilk A, Shin S-Y, Glass D, Travers M, Min JL, Zondervan KT, Ring S, McArdle W, Thorleifsson G, Kong A, Thorsteindottir U, Ainali C, Dimas AS, Hassanali N, Ingle C, Knowles D, Krestyaninova M, Lowe CE, Meduri E, di Meglio P, Montgomery SB, Parts L, Potter S, Surdulescu G, Tsaprouni T, Tsoka S, Bataille V, Durbin R, Nestle FO, O’Rahilly S, Lindgren CM, Soranzo N, Ahmadi K, Schadt E, Stefansson K, Davey-Smith G, McCarthy MI*, Deloukas P*, Dermitzakis ET*, Spector TD*, for the MuTHER consortium. 2012. Mapping cis and trans regulatory effects across multiple tissues in twins: the MuTHER Study. Nature Genetics, 44(10):1084-1089. Link

Bell JT*, Tsai P-C*, Yang T-P, Pidsley R, Nisbet J, Glass D, Zhai G, Mangino M, Zhai G, Zhang F, Valdes A, Shin S-Y, Dempster EL, Murray RM, Grundberg E, Hedman AK, Nica A, Small KS, The MuTHER Consortium, Dermitzakis ET, McCarthy MI, Mill J, Spector TD*, Deloukas P*. 2012. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genetics, 8(4):e1002629. Link. Highlighted in New Scientist The Independent Huffington Post

Bell JT and Saffery R. 2012. The value of twins in epigenetic epidemiology. International Journal of Epidemiology, 41(1): 140-150. Link

2011



Bell JT and Spector TD. 2011. A Twin approach to unraveling Epigenetics. Trends in Genetics, 27: 116-125. Link

Nica AC, Parts L, Glass D, Nisbet J, Barrett A, Sekowska M, Ingle C, Travers M, Potter S, Grundberg E, Small K, Hedman A, Bataille V, Tzenova Bell J, Surdulescu G, Dimas AS, Nestle FO, di Meglio P, Min JL, Wilk A, Hammond CJ, Hassanali N, Yang T-P, Montgomery SB, Lindgren CM, Zondervan KT, Soranzo N, Barroso I, Durbin R, Ahmadi K, Deloukas P, McCarthy MI, Dermitzakis ET, Spector TD, for the MuTHER Consortium. 2011. The architecture of regulatory gene variation across multiple human tissues: the MuTHER study. PLoS Genetics, 7(2):e1002003. Link

Zhai G*, Teumer A*, Stolk L*, Perry J*, Vandenput L*, Coviello D*, Koster A*, Bell JT, Bhasin S, Eriksson J, Eriksson A, Ernst F, Ferrucci L, Frayling TM, Glass D, Grundberg E, Haring R, Hedman AK, Hofman A, Kiel DP, Kroemer HK, Liu Y, Lunetta KL, Lorentzon M, Mangino M, Melzer D, Miljkovic I, MuTHER consortium, Nica A, Penninx B, Ramachandran V, Small KS, Soranzo N, Uitterlinden AG, Vlzke H, Wilson S, Zhuang WV, Harris T*, Murabito JM*, Ohlsson C*, Murray A*, de Jong F*, Spector TD*, and Wallaschofski H*. 2011. Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genetics, 7(4):e1002025. Link